Marissa Williams

 

Williams M

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Marissa is currently a Postdoctoral fellow at the Asbestos Diseases Research Institute (ADRI) where she is involved in projects that explore the role of microRNAs in mesothelioma chemo-resistance and immunotherapy response. Marissa has recently completed her PhD studies that investigated mechanisms driving microRNA downregulation in malignant pleural mesothelioma (MPM) and characterised microRNA involvement in MPM drug resistance. She was fortunate to be awarded a full PhD scholarship from Sydney Catalyst to support her studies at the University of Sydney.

Marissa has a Bachelor of Forensic Biology in Biomedical Science (2010) with Honours (2011) from the University of Technology and commenced her PhD candidature at the University of Sydney in 2015.

 

RESEARCH INTERESTS:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

 

Abstract:

Multiple mechanisms contribute to downregulation of tumour suppressor mircoRNAs in malignant pleural mesothelioma

Background: Malignant pleural mesothelioma (MPM) is a disease with an almost invariably fatal diagnosis with limited therapeutic options. Characteristic patterns of deregulation microRNA expression have been demonstrated in MPM, and many downregulated microRNAs have been shown to have tumour suppressor activity. However, apart from silencing of miR-34b/c by promoter hypermethylation and co-deletion of miR-31 with the CDKN2A locus, the mechanisms responsible for the downregulation of other tumour suppressor miRNAs, such as miR-16 are yet to be elucidated.

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